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Induction Immunochemotherapy in Stage III-IVa Head and Neck Cancer

Neck Cancer Clinical Trial

Official title:
Induction Immunochemotherapy in Stage III-IVa Cancer of Oropharynx, Hypopharynx and Larynx

Clinical Trial Summary

patients with locally advanced cancer of oropharynx, hypopharynx or larynx and CPS>1 will recieve 3 cycles of induction immunochemotherapy with platinum, 5-FU and pembrolizumab followed by (chemo)radiation.

Clinical Trial Description

patients with locally advanced cancer of oropharynx, hypopharynx or larynx and CPS>1 will recieve 3 cycles of induction immunochemotherapy with platinum (cisplatin 75 mg\m2, 5-FU 1000 mg/m2/day 96-hour infusion and pembrolizumab 200 mg) followed by (chemo)radiation. Effect of induction therapy will be assesed by PET/CT and by endoscopic evaluation with biopsy of suspected residual tumor. Managemant of any residual tumor will be performed according with local rules and standards. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05551767
Study type Interventional
Source City Clinical Oncology Hospital No 1
Contact Ilya ? Pokataev
Phone +79262858986
Email pokia@mail.ru
Status Recruiting
Phase Phase 2
Start date August 30, 2022
Completion date December 30, 2024
View Details
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