Natural Killer Cell Deficiency, Familial Isolated Clinical Trial
Official title:
The Natural Killer Cells Regulatory Role Against Hepatic Fibrosis Following Bariatric Surgery
This study will determine the role of the NK cells before and after bariatric surgery. The
investigators selected patients with NAFLD.
A Fibroscan evaluation will be assessed as a new modality to evaluate liver fibrosis.
All morbidly obese patients who are candidates for a bariatric procedure in the
investigators institution who has a fatty liver in their routine preoperative US will
undergo a fibroscan to assess the degree of liver fibrosis preoperatively in addition to a
blood sample that will be withdrawn from those participants to isolate the NK cells and to
assess their activities by the assessment of the active form of NK cells (CD107a) using the
spectrometry (FACS) analysis.
The investigators will also collect other clinical data including comorbidities
(hypertension, diabetes mellitus and hyperlipidemia) in addition to the following routine
blood test( complete blood count, creatinine, urea, International normalized ratio, liver
function test, HBa1C, cholesterol, HDL, LDL, triglycerides, vitamin D, vitamin B12,
potassium, sodium, albumin, bilirubin, C- reactive protein, iron, ferritin and transferrin).
All of the above mentioned tests including the NK cells and the fibroscan will be examined
for all participants in 3, 6, 12 months postoperatively.
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Observational Model: Case Control, Time Perspective: Prospective