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Nasopharyngeal Neoplasms clinical trials

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NCT ID: NCT03047525 Recruiting - Colorectal Cancer Clinical Trials

Study of DC-CTL Combined With CIK for Advanced Solid Tumor

Start date: February 20, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

Background: Combinations of Dendritic and Cytokine-induced Killer Cells (DC-CIK) and Cytokine-induced Killer Cells (CIK) treatment may enhance the immune response and stop cancer cells from growing. The investigators suppose that DC-CIK combined with CIK treatment will improve the prognosis of advanced solid tumors. Objective: Phase II clinical trial to investigate the efficacy of concurrent chemotherapy with DC-CIK and CIK treatment in patients with treatment-refractory solid tumors. Study treatment: Patients in group A will receive 4 cycles of CIK treatments and 4 cycles of DC-CIK treatments within 8 months. Patients in group B will have no immunotherapy . chemotherapy are available in both groups.

NCT ID: NCT03045484 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Comparison of Oxycodone to Control Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy

Start date: May 2016
Phase: N/A
Study type: Interventional

Background:Although concurrent chemoradiotherapy is effective for improving disease-free survival and overall survival in patients with locally advanced nasopharyngeal carcinoma. However,the oral mucositis pain evoked by the chemoradiotherapy itself reduces food intake and frequently halts the treatment. Thus, pain control is an important problem in chemoradiotherapy for nasopharyngeal carcinoma.We performed to examine whether early induction of low-dose, opioid from moderate pain reduced total dose of Oxycodone during chemoradiotherapy, while improves the quality of life and reduce weight loss. Objective:Present clinical trial to investigate the early introduction of opioids suppressed the transient increase in the numeric rating scales(NRS) score for pain and compared with conventional treatment. Methodology:The subjects will recruit 70 patients who were hospitalized for nasopharyngeal carcinoma. 70 patients were divided into two groups, depending on whether the pain was moderate or severe when an opioid was introduced.Differences between groups were compared using T test protected least significant difference for one-factor analysis of variance. All statistical analyses were performed using SPSS(Statistic Package for Social Science) software.P-values < 0.05 were considered statistically significant.

NCT ID: NCT03044743 Recruiting - Clinical trials for Stage IV Adult Hodgkin Lymphoma

PD-1 Knockout EBV-CTLs for Advanced Stage Epstein-Barr Virus (EBV) Associated Malignancies

Start date: April 7, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

This study will evaluate the safety of PD-1 knockout EBV-CTL cells in treating EBV (Epstein-Barr virus) positive advanced stage malignancies. Blood samples will also be collected for research purposes.

NCT ID: NCT03015727 Recruiting - Clinical trials for Locally Advanced Nasopharyngeal Carcinoma

Induction Chemotherapy Followed by Radiotherapy Alone or Concurrent Chemoradiotherapy in Nasopharyngeal Carcinoma

IRCNPC
Start date: December 2016
Phase: Phase 3
Study type: Interventional

In this study, the investigators aim to compare the progression-free survival (PFS) and side effects of radiotherapy (RT) and concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC) patients with a satisfactory tumor response (complete response or partial response) after neoadjuvant chemotherapy (NACT).

NCT ID: NCT03006588 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

EUS-FNA for Retropharyngeal Lymph Node (RPLN) in Recurrent Nasopharyngeal Carcinoma (NPC) Patients

Start date: January 2014
Phase: Phase 2/Phase 3
Study type: Interventional

EUS-FNA for RPLN in NPC

NCT ID: NCT03003182 Recruiting - Clinical trials for Nasopharyngeal Cancer

A Study of Nasopharyngeal Carcinoma From Guangdong

Start date: May 10, 2017
Phase: N/A
Study type: Observational

This prospective cohort study aims to establish prognostic models, to discover toxicity associated predictors and to validate randomized trials in clinical practice.

NCT ID: NCT02980315 Recruiting - Clinical trials for Nasopharyngeal Neoplasms

A New EBV Related Technologies of T Cells in Treating Malignant Tumors and Clinical Application

Start date: November 2016
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety of the designed LMP1-CAR -T cells and determine whether the CAR-T cells are effective in the treatment of EBV associated malignant tumors.

NCT ID: NCT02945878 Recruiting - Clinical trials for Nasopharyngeal Neoplasms

Predictive Factors of Acute Oral Mucositis Induced by Chemo-radiotherapy for Local Advanced Nasopharyngeal Carcinoma

Start date: October 2016
Phase: N/A
Study type: Observational

This is a prospective, observational study to analyze the clinical and dosimetric factors about the radiation oral mucositis caused by radical chemo-radiotherapy for nasopharyngeal carcinoma patients and try to find the indicators for acute radiation oral mucositis.

NCT ID: NCT02944708 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Trial Evaluating Maintenance Chemotherapy for Metastatic Nasopharyngeal Carcinoma

Start date: October 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to examine the efficacy of maintenance chemotherapy for the treatment of metastatic nasopharyngeal carcinoma. Participants will be randomized to 3 arms. Arm 1, control group, participants will receive only 4-8 cycles of conventional chemotherapy; arm 2, participants will receive 6 cycles of maintenance chemotherapy after conventional chemotherapy; arm 3, experiment arm, after conventional chemotherapy, participants will receive maintenance chemotherapy until disease progression or intolerable toxicities.

NCT ID: NCT02937519 Recruiting - Clinical trials for Esophageal Neoplasms

Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer

Start date: June 2015
Phase: Phase 2
Study type: Interventional

1. Observe and compare the chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy term efficacy of the treatment of locally advanced nasopharyngeal carcinoma. 2. Evaluation chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy in locally advanced nasopharyngeal carcinoma safety and tolerability. 3)observing the adverse reaction and effects of two groups,expected chrono-chemotherapy group can achieve lower toxicity, improve the curative effect, for the treatment of nasopharyngeal carcinoma provides a more reasonable way.