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18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study

Nasopharyngeal Carcinoma Clinical Trial

Official title:
18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study

Clinical Trial Summary

This study aims to investigate the use of 18F-FMISO PET in identifying hypoxic subvolume for dose escalation radiotherapy in nasopharyngeal cancer and thus improve local control without significant increase in toxicities.

Clinical Trial Description

The specific aims of this study are: 1. To establish hypoxia imaging in NPC patients 2. Investigate the dynamics of tumor hypoxia before and during chemoradiation 3. Integrate hypoxia imaging into radiation treatment planning protocols 4. Design hypoxia adapted radiation schedules 5. Identify candidate hypoxia biomarkers ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04995185
Study type Interventional
Source National Cancer Centre, Singapore
Contact
Status Completed
Phase N/A
Start date June 20, 2017
Completion date December 30, 2020
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