Demethylated Drug in the Treatment of Nasopharyngeal Carcinoma

Status Recruiting

Clinical Trial Summary

The study is to observe the efficacy and toxicity of demethylating drug decitabine and cisplatin induced chemotherapy for 3 cycles followed by concurrent chemoradiotherapy in the treatment of regionally advanced nasopharyngeal carcinoma,followed up for 2 years, observing the 2-year survival rate and variation of degrees of methylation before and after treatment,providing clinical basis for the clinical study of stage II-III.

Clinical Trial Description

Recent studies and previous studies in the investigator's research group have found that nasopharyngeal carcinoma is a disease with hypermethylation changes, and epigenetic treatment has not yet been carried out in nasopharyngeal carcinoma. In this study, Simon's two-stage design method was used to select 30 patients with nasopharyngeal carcinoma, treated with demethylating drug decitabine 7mg/m2 d1-5 + cisplatin 80mg/m2 d1 induced chemotherapy for 3 cycles followed by concurrent chemoradiotherapy with cisplatin 80mg/m2. observing the efficacy and toxicity of decitabine in the treatment of regionally advanced nasopharyngeal carcinoma, followed up for 2 years, observing the 2-year survival rate,evluating the relationship between different degrees of methylation and survival before and after treatment,provide clinical basis for the clinical study of stage II-III. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03701451
Study type	Interventional
Source	Guilin Medical University, China
Contact	Rongjun Zhang, Master
Phone	+86-18977330177
Email	41974954@qq.com
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	February 28, 2018
Completion date	December 1, 2020

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