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Estrogen Administration for the Treatment of NASH in Postmenopausal Women

NASH - Nonalcoholic Steatohepatitis Clinical Trial

Official title:
Estrogen Administration for the Treatment of NASH in Postmenopausal Women

Clinical Trial Summary

Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited. Preclinical and preliminary clinical data suggest that estrogen deficiency plays an important role in the pathology of steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Post-menopausal women are a growing population with particularly high risk of NASH due to their lack of estrogen. This study will examine the effect of estradiol on hepatic fibrosis and fat in post-menopausal women with NASH.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Fatty Liver
  • NASH - Nonalcoholic Steatohepatitis
  • Non-alcoholic Fatty Liver Disease
Clinical Trial Details
NCT number NCT04833140
Study type Interventional
Source Massachusetts General Hospital
Contact Anu Gerweck, NP
Phone 617-724-1837
Email avgerweck@mgh.harvard.edu
Status Recruiting
Phase Phase 3
Start date December 2, 2021
Completion date May 31, 2027
View Details
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