Myocarditis Clinical Trial
Official title:
The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Children With Acute Inflammatory Cardiomyopathy
Children can have or develop certain problems with their heart function, specifically with
the heart muscle or myocardium. This problem can be caused by many things specifically by
infection resulting in myocarditis (inflammation of the heart muscle) or dilated
cardiomyopathy (caused by many factors including high blood pressure and heart attacks). The
body goes through many processes to repair the injured tissue including using proteins that
cause the muscle mass to increase called matrix metalloproteinases (MMPs). The body also
uses proteins that direct the MMPs to stop increasing the muscle mass called tissue
inhibitory of metalloproteinases (TIMPs). Currently, there are no published studies that
explain or evaluate the relationship that MMPs and TIMPs have in myocarditis and dilated
cardiomyopathy in children.
The investigator wishes to perform a prospective study of the serum levels of these proteins
and their regulators in children with myocarditis and/or dilated cardiomyopathy and compare
them with children that have no heart disease.
All children who present with signs and symptoms of myocarditis and have laboratory findings
consistent with cardiomyopathy will be eligible. After prospective consent, all subjects
will receive: (1) a complete physical examination, (2) complete transthoracic echocardiogram
to better characterize the disease process. Follow-up echocardiograms will be performed at
24-72 hours after admission into the protocol and at discharge from the hospital.
Approximately 2 teaspoons of blood will be drawn at: (1) enrollment, (2) 24 hours after, (3)
72 hours after, (4) and at hospital discharge. Those subjects that receive a heart
transplant will have blood drawn at the time of transplantation. For those that have a
cardiac catheterization or have a muscle biopsy as part of their standard of care, will also
have a biopsy of their right ventricle performed.
Data to be collected: Minimum patient demographic data (age, sex, ethnic origin), vital
signs, clinical course events/data (i.e. need for dialysis, length of stay, surgical time
points, etc), diagnostic test results (EKGs, ECHOs, etc), significant medical history data,
and standard of care laboratory results.
The investigator wishes to evaluate the relationship of this data with the patient's
diagnosis, clinical course, and serum levels of MMP and TIMP proteinases.
;
Observational Model: Case Control, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05911386 -
Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
|
||
Not yet recruiting |
NCT04085718 -
FDG-PET/CT Images Comparing to MRI and Endomyocardial Biopsy in Myocarditis
|
||
Enrolling by invitation |
NCT05610423 -
Covid-19 Vaccine Associated Myocarditis and Pericarditis in Norway
|
||
Active, not recruiting |
NCT05195645 -
AbataCept for the Treatment of Immune-cHeckpoint Inhibitors Induced mYocarditiS
|
Phase 2 | |
Recruiting |
NCT05184114 -
Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients Using Cardiovascular Magnetic Resonance
|
N/A | |
Recruiting |
NCT04612296 -
The Heart Hive - Cardiomyopathy Study
|
||
Recruiting |
NCT04673409 -
CMR Imaging of Autoimmune Diseases
|
||
Recruiting |
NCT05295290 -
A Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.
|
Phase 4 | |
Completed |
NCT03777839 -
PET-FDG in Myocarditis
|
||
Not yet recruiting |
NCT05125965 -
Contribution of Cardiac MRI in the Early Diagnosis of Myocarditis Induced by Immunotherapy
|
N/A | |
Active, not recruiting |
NCT04444128 -
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
|
||
Recruiting |
NCT06158698 -
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
|
Phase 3 | |
Recruiting |
NCT05288426 -
Myocarditis Post Vaccination or Multi System Inflammatory Syndrome
|
||
Recruiting |
NCT05282498 -
Pathophysiologic Mechanism for MYOcarditis in COVID19 VAccinations ("MYOVAx" Study)
|
||
Recruiting |
NCT03801681 -
ARrhythmias in MYocarditis
|
||
Recruiting |
NCT06116084 -
Randomized Controlled Study Evaluating the Efficacy of Hypnosis in Nuclear Medicine
|
N/A | |
Completed |
NCT04413071 -
Cardiac COVID-19 Health Care Workers
|
||
Recruiting |
NCT05414162 -
Multiparametric Cardiac MRI in Patients Under CAR T-cell Therapy
|
||
Completed |
NCT02299856 -
Cardiac Magnetic Resonance in Acute Myocarditis
|
N/A | |
Recruiting |
NCT01089036 -
Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients
|
N/A |