Myocarditis Clinical Trial
Official title:
The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Children With Acute Inflammatory Cardiomyopathy
Children can have or develop certain problems with their heart function, specifically with
the heart muscle or myocardium. This problem can be caused by many things specifically by
infection resulting in myocarditis (inflammation of the heart muscle) or dilated
cardiomyopathy (caused by many factors including high blood pressure and heart attacks). The
body goes through many processes to repair the injured tissue including using proteins that
cause the muscle mass to increase called matrix metalloproteinases (MMPs). The body also
uses proteins that direct the MMPs to stop increasing the muscle mass called tissue
inhibitory of metalloproteinases (TIMPs). Currently, there are no published studies that
explain or evaluate the relationship that MMPs and TIMPs have in myocarditis and dilated
cardiomyopathy in children.
The investigator wishes to perform a prospective study of the serum levels of these proteins
and their regulators in children with myocarditis and/or dilated cardiomyopathy and compare
them with children that have no heart disease.
Status | Completed |
Enrollment | 36 |
Est. completion date | July 2006 |
Est. primary completion date | July 2006 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A to 18 Years |
Eligibility |
Inclusion Criteria: 1. Evidence from diagnostic tests and physical exam that confirm inflammatory cardiomyopathy. Exclusion Criteria: 1. Patients with structural heart disease other than septal defects or patent ductus arteriosus 2. Patients with history of arrhythmia 3. Patients with history of ventricular dysfunction diagnosed by echocardiograms 4. Patients with history of chronic systemic illness |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Children's Medical Center | Dallas | Texas |
Lead Sponsor | Collaborator |
---|---|
University of Texas Southwestern Medical Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determine correlation between proteinases (MMPs and TIMPs) and their regulators in children with acute inflammatory cardiomyopathy. | Length of hospital stay from time of admission to protocol. | No |
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