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E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

Coronary Artery Disease Clinical Trial

Official title:
E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

Clinical Trial Summary

E-cigarettes deliver nicotine by creating an aerosol of ultrafine particles. Many questions remain about the size and composition and especially about the potential toxicity of these particles. Thus, a key unanswered question-and the research question proposed-is whether e-cigarette aerosol triggers the same acute impairment in coronary microvessel function as does conventional cigarette smoke, which delivers a very well-defined exposure to fine particles and many fold greater exposure to toxic (combustion) products including volatile organic compounds (such as acrolein) that have been implicated in the pathogenesis of tobacco-related coronary disease. Because the effects of nicotine on the human coronary microcirculation remain incompletely defined-with multiple potential vasodilator and vasoconstrictor actions each of which may vary by dose-we will determine the comparative effects of conventional cigarette smoke against e-cigarette aerosol with no nicotine, with low-dose nicotine, and with high-dose nicotine.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02612701
Study type Interventional
Source Cedars-Sinai Medical Center
Contact
Status Terminated
Phase N/A
Start date October 2015
Completion date October 2020
View Details
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