Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

Myocardial Injury Clinical Trial

— TRIMRIPC  

Official title:

Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01308138
• Other study ID #: TRIMRIPC
• Status: Completed
• Phase: N/A
• First received: February 2, 2011
• Last updated: August 19, 2015
• Start date: January 2011
• Est. completion date: July 2013

Study information

• Verified date: August 2015
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway:National Committee for Medical and Health Research Ethics
• Study type: Interventional

Clinical Trial Summary

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: July 2013
• Est. primary completion date: May 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria:

• myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Myocardial Injury

Intervention

Behavioral:
• Exercise training
exercise training

Procedure:
• remote ischemic preconditioning
remote ischemic preconditioning

Locations

Country	Name	City	State
Norway	Norwegian University of Science and Technology, Medical Faculty	Trondheim	Sør-Trondelag

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	St. Olavs Hospital

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Slagsvold KH, Moreira JB, Rognmo O, Høydal M, Bye A, Wisløff U, Wahba A. Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: a randomized trial. Int J — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Mitochondrial respiration	Oxygraph (Strathkelvin)	1 hour	No