Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery

Status Completed

Clinical Trial Summary

Animal studies have shown that preconditioning with hyperbaric oxygen can induce central nervous system and heart ischemic tolerance. This study was designed to determine the protective effect of hyperbaric oxygen preconditioning on brain and myocardium ischemia-reperfusion injury during coronary artery bypass graft surgery.

Clinical Trial Description

60 patients scheduled to undergo coronary revascularization were recruited for this trial. Exclusion criteria included Emergency operation, age older than 80 years, learning difficulty, previous cerebrovascular disease, visual or hearing impairment, history of pneumothorax, Claustrophobia, middle ear disease, EF < 35%. Patients were randomized either to the control group or hyperbaric oxygen group. The laboratory analysis of markers included S100B, NSE and troponin I. The assessment of cognitive dysfunction was performed 5 days before surgery and 7 days after surgery and haemodynamic measurements, length of stay in ICU, length of stay in hospital post-operation were recorded. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00817791
Study type	Interventional
Source	Xijing Hospital
Contact
Status	Completed
Phase	N/A
Start date	November 2007
Completion date	March 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02710123` - Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion	N/A
Recruiting	`NCT02777060` - Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures	N/A
Completed	`NCT02262286` - MIND (Management of Traumatic Brain Injury Diagnosis)	N/A
Completed	`NCT01461902` - Vasospasm in Pediatric Traumatic Brain Injury	N/A
Recruiting	`NCT01198964` - Optimization of Human Cortical Stimulation
Active, not recruiting	`NCT01207050` - Effect of Rozerem on Sleep Among People With Traumatic Brain Injury	Phase 4
Completed	`NCT01201863` - Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy	Phase 4
Completed	`NCT00875329` - Traumatic Brain Injury (TBI) Screening Instruments	N/A
Completed	`NCT01059890` - Cerebral Antibiotics Distribution After Acute Brain Injury	Phase 1
Completed	`NCT01035606` - Training in Goal-directed Attention Regulation for Individuals With Brain Injury	N/A
Completed	`NCT00571623` - Automated Chest Physiotherapy to Improve Outcomes in Neuro	N/A
Completed	`NCT00596765` - Neuropsychological Cognitive Behavioral Therapy for Patients With Acquired Brain Injury	N/A
Completed	`NCT00336466` - The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS)	Phase 2
Recruiting	`NCT05105763` - Biofeedback Gait Retraining for Stiff Knee Gait Correction	N/A
Recruiting	`NCT02495558` - Cough Assessment in Patients With Severe Acquired Brain Injury	N/A
Completed	`NCT02100592` - Early Verticalization in neuroICU With ERIGO: a Safety and Feasibility Study	Phase 1/Phase 2
Completed	`NCT00797680` - Duration of Hypothermia for Neuroprotection After Pediatric Cardiac Arrest	Phase 2
Completed	`NCT00018499` - Genotype Influence on Recovery After Traumatic Brain Injury	N/A
Recruiting	`NCT02567201` - Electrophysiological Evaluation of Voluntary Attention	N/A
Withdrawn	`NCT05581927` - Whole-Body Hypothermia for Neonates With Hypoxic-Ischemic Encephalopathy(HIE)	N/A