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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04437927
Other study ID # 20-11
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 7, 2020
Est. completion date November 6, 2020

Study information

Verified date June 2020
Source Centre Hospitalier Princesse Grace
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

There is increasing evidence that [18F]-2-fluoro-2-deoxy-D-glucose (18F-FDG) PET/CT is useful in the identification and treatment of disease processes that involve cardiac inflammation and infection. Current applications include imaging intra-cardiac device and prosthetic valve infections, evaluating patients with known or suspected cardiac sarcoidosis or other inflammatory cardiomyopathies. However, because normal myocardium can metabolize both glucose and free fatty acids (FFAs), physiological accumulation of FDG in the myocardium can interfere with the recognition of abnormal FDG uptake. The use of a low-carbohydrate diet with a prolonged fast ≥ 12 h nutrition followed by a fast of at least four hours is the effective preparation recommended to suppress physiological myocardial FDG uptake. However, the rate of suppression of physiological accumulation of FDG with this method in our center is only 50%.


Description:

Methodology : Group of 30 consecutive patients with cardiac FDG PET prescribed, prospectively enrolled, compared to a group with the last 30 patients referred for cardiac FDG PET in the nuclear medicine department of the Centre Hospitalier Princesse Grace. Procedures : Infusion of 100mL lipid emulsion for intravenous two hours before cardiac FDG PET/CT: - Infusion rate will be 20 mL/hour during the initial 10 minutes (3 mL Intralipid) - The dose will be then increased to 40 mL/hour for the next 10 minutes (6 mL Intralipid) - Finally, for the next 50 minutes the dose will be increased to 100 mL/hour (83mL Intralipid)


Recruitment information / eligibility

Status Completed
Enrollment 51
Est. completion date November 6, 2020
Est. primary completion date November 6, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 99 Years
Eligibility Inclusion Criteria: - Patients with an FDG PET/CT prescribed to explore cardiac disease process Exclusion Criteria: - renal insufficiency, - uncompensated diabetes mellitus, - pancreatitis, - liver insufficiency, - hypothyroidism - metabolic disorders - sepsis. - soy protein allergy

Study Design


Locations

Country Name City State
Monaco Centre Hospitalier Princesse Grace Monaco

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Princesse Grace

Country where clinical trial is conducted

Monaco, 

Outcome

Type Measure Description Time frame Safety issue
Primary Uptake in the heart scoring according to a visual scale Score of 0: complete myocardial suppression
Score of 1: incomplete myocardial suppression with increased myocardial FDG uptake hampering myocardial interpretation but not cardiac valves.
Score of 2: incomplete myocardial suppression with increased myocardial FDG uptake hampering myocardial and mitral or aortic valve interpretations.
Score of 3: incomplete myocardial suppression with increased myocardial FDG uptake hampering myocardial and both mitral and aortic valves interpretations.
day 1
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