Myocardial Inflammation Clinical Trial
Official title:
Impact of 100mL Lipid Emulsion for Intravenous for Suppression of Myocardial Glucose
NCT number | NCT04437927 |
Other study ID # | 20-11 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | April 7, 2020 |
Est. completion date | November 6, 2020 |
Verified date | June 2020 |
Source | Centre Hospitalier Princesse Grace |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
There is increasing evidence that [18F]-2-fluoro-2-deoxy-D-glucose (18F-FDG) PET/CT is useful in the identification and treatment of disease processes that involve cardiac inflammation and infection. Current applications include imaging intra-cardiac device and prosthetic valve infections, evaluating patients with known or suspected cardiac sarcoidosis or other inflammatory cardiomyopathies. However, because normal myocardium can metabolize both glucose and free fatty acids (FFAs), physiological accumulation of FDG in the myocardium can interfere with the recognition of abnormal FDG uptake. The use of a low-carbohydrate diet with a prolonged fast ≥ 12 h nutrition followed by a fast of at least four hours is the effective preparation recommended to suppress physiological myocardial FDG uptake. However, the rate of suppression of physiological accumulation of FDG with this method in our center is only 50%.
Status | Completed |
Enrollment | 51 |
Est. completion date | November 6, 2020 |
Est. primary completion date | November 6, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - Patients with an FDG PET/CT prescribed to explore cardiac disease process Exclusion Criteria: - renal insufficiency, - uncompensated diabetes mellitus, - pancreatitis, - liver insufficiency, - hypothyroidism - metabolic disorders - sepsis. - soy protein allergy |
Country | Name | City | State |
---|---|---|---|
Monaco | Centre Hospitalier Princesse Grace | Monaco |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Princesse Grace |
Monaco,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Uptake in the heart scoring according to a visual scale | Score of 0: complete myocardial suppression
Score of 1: incomplete myocardial suppression with increased myocardial FDG uptake hampering myocardial interpretation but not cardiac valves. Score of 2: incomplete myocardial suppression with increased myocardial FDG uptake hampering myocardial and mitral or aortic valve interpretations. Score of 3: incomplete myocardial suppression with increased myocardial FDG uptake hampering myocardial and both mitral and aortic valves interpretations. |
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