Heart Failure Clinical Trial
Official title:
Assessment of the Relationship Between Collagen Turnover, Left Ventricular Remodelling and Myocardial Scarring Assessed by Cardiac Magnetic Resonance and Neurohumoral Activation in Patients With Previous Myocardial Infarction
This study will assess the relationship between collagen turnover, neurohormonal activation, scarring and left ventricle remodelling in patients 3 years following a myocardial infarction.
A multinational trial compared losartan vs. captopril in 5477 postinfarction patients with
symptoms of heart failure and/or evidence of left ventricular dysfunction. The trial was
terminated in 2002 and the results of the main trial have been published. In this trial, a
collagen and neurohumoral substudy was performed to assess the importance of collagen
turnover in this population. A total of 235 patients were included from 18 centres. Blood
was taken at randomisation, 1 month, 1 year and 2 years.
The present study will recruit surviving patients among the 119 individuals that were
randomised to the neurohumoral substudy at the Stavanger University Hospital. The study will
assess the relationship between collagen turnover, neurohormonal activation, scarring and
left ventricle remodelling in these patients about 3 years following the index myocardial
infarction.
The data collected at the 3-year follow-up visit will be compared to data from the initial
study.
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Observational Model: Cohort, Time Perspective: Retrospective
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