Healthy Clinical Trial
Official title:
Molecular MRI of the Fibrotic Heart
This study is a feasibility study to validate magnetizatin transfer (MT)-weighted balanced steady state free precession (bSSFP) cine cardiac magnetic resonance (CMR) against current clinical gold standard diagnostics, and to determine the applicability of MT-weighted bSSFP cine CMR for diagnosis of fibrotic remodeling in chronic kidney disease (CKD5) patients. Participants will not receive a study drug or placebo and will not be randomized. A total of 250 participants will be enrolled into this study.
This study had two treatment arms.
Arm 1: Participants will be enrolled in this arm if they have been referred to the Gill Heart
Institute MRI center for diagnostic late gadolinium enhancement (LGE) -CMR imaging of
fibrosis, or if they are a healthy volunteer.
If a participant is a Gill Heart Institute referral patient , they will receive an
intravenous (through a vein in the arm) infusion of gadolinium as part of their clinical
examination. Participants will also have electrocardiogram (ECG) waveform performed in order
to gate the MRI scan. The MRI scan of the heart, for which the participant has been referred
will last approximately 1 hour. Participants will have an additional 5-10 minutes of scans
performed, none of which require additional infusions.
If the participant is a healthy volunteer, they will have an ECG waveform performed in order
to gate your MRI scan, and they will have approximately 30-45 minutes of scanning performed
on their heart. Participants will not receive an infusion of gadolinium.
Arm 2: Only participants who are already participating in a study being conducted by Dr.
Harmut Malluche at the University of Kentucky, Department of Nephrology or, if you are a
healthy volunteer, will be enrolled into this arm.
In this arm participants will receive an MRI of their heart, lasting 30-45 minutes.
Participants will not receive an infusion of gadolinium.
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