Chronic Myelomonocytic Leukemia Clinical Trial
Official title:
A Phase 1b/2 Study to Evaluate the Safety and Efficacy of APR-246 in Combination With Azacitidine for the Treatment of Mutation TP53 (TP53) Mutant Myeloid Neoplasms
The main purpose of this study is to determine the safe and efficacy of APR-246 in combination with azacitidine as well as to see complete remission of this patients
Patients will be treated for a total of 6 cycles.For patients responding or who have stable
disease following cycle 6, treatment may continue until one of the following criteria
applies:
- Inter-current illness that prevent further administration of treatment
- Unacceptable adverse event(s)
- Participant decides to withdraw from the study,
- general or specific changes in the participant's condition render the participant
unacceptable for further treatment in the judgment of the investigator.
- Evidence of disease progression by international working Group (IWG) 2006 criteria.
- participants who wish not to continue treatment at time of disease assessment at end of
cycle 6 will complete their end of treatment visit upon completion of cycle 6
;
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