Myeloproliferative Neoplasm Clinical Trial
Official title:
Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of Chronic Philadelphia Negative Myeloproliferative Neoplasms
Patients with myeloproliferative neoplasms Philadelphia chromosome negative (MPNsPh1-) such
as Essential thrombocytosis (ET), Polycythemia vera (PV) and Primary Myelofibrosis (PMF) have
a higher risk of arterial or deep-vein thrombosis. This is responsible for a significant
increase in mortality (up to 31% of increase in thrombosis risk in ET). Cellular inflation
and blood hyperviscosity, resulting from these diseases, fail to account for these
thromboses, as more than 50% of thrombotic complications happen under adapted antineoplastic
drug treatment.
These last years, cellular microparticles (MPs) have been shown to play a major role in
thrombogenesis. MPs are generated by apoptosis or the activation of malignant cells,
platelets, endothelial cells or monocytes. They are fragments of plasma membrane, smaller
than 1 µm, rich in phosphatidylserine, which can express the tissue factor and serve as
support for the coagulation factors. Increase in the plasma concentration of procoagulant
platelet microparticles has been demonstrated in other thrombotic diseases (acute coronary
syndrome, disseminated intravascular coagulation DIC, etc.). The working hypothesis is that
platelet microparticles are involved in the hypercoagulability of MPNs patients.
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