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Clinical Trial Summary

The purpose of this study is to assess the safety, pharmacokinetic profile of APG-2575 single agent and in combination with HHT/AZA in patients with relapsed/refractory AML and related myeloid malignancies.


Clinical Trial Description

This is an open-label, multi-center Phase Ib study of safety, PK of APG-2575 as single agent or in combination with HHT or AZA in relapsed/refractory AML and related myeloid malignancies patients. This study consists of three stages: The first stage is the APG-2575 single agent dose-escalation study. The second stage is the APG-2575 combined with HHT/AZA dose-escalation study. The third stage is the MTD/RP2D expansion cohort study of the combination regimen. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04501120
Study type Interventional
Source Ascentage Pharma Group Inc.
Contact Jie Jin, M.D.
Phone +86 571-87236896
Email jiej0503@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date September 28, 2020
Completion date August 2025

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