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Clinical Trial Summary

To learn if luspatercept is more effective in helping to reduce the number of blood transfusions needed by patients with LR-MDS.


Clinical Trial Description

Objectives: Primary Objectives: - To assess the clinical activity and safety of luspatercept in patients with transfusion independent lower risk MDS - To assess the clinical activity and safety of luspatercept in patients with transfusion dependent lower risk MDS - To study the effects on hematopoeisis of luspatercept in patients treated on this study Secondary Objectives: - To assess the duration of response of patients with treated with luspatercept in this study - To assess the overall survival and time to transformation of patients with treated with luspatercept in this study - To assess transfusion free survival period in patients that were transfusion independent treated with luspatercept in this study - To measure trends in neutrophil and platelet counts in patients treated in this study ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06113302
Study type Interventional
Source M.D. Anderson Cancer Center
Contact Guillermo Garcia-Manero, M D
Phone (713) 745-3428
Email ggarciam@mdanderson.org
Status Recruiting
Phase Early Phase 1
Start date March 1, 2024
Completion date June 2, 2026

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