Anemia Clinical Trial
Official title:
Post Transplant Infusion of Allogeneic Cytokine Induced Killer Cells as Consolidative Therapy After Non-Myeloablative Allogeneic Transplantation in Patients With Myelodysplasia or Myeloproliferative Disorders
Allogeneic stem cell transplantation (transplant of blood cells from another individual) is a treatment option for patients with myelodysplasia or myeloproliferative Disorders. During the course of this study, it will be evaluated whether a particular type of blood cell, called a cytokine-induced killer (CIK) cell, may add benefit to allogeneic stem cell transplantation. CIK cells are present in small quantities in the bloodstream but their numbers can be expanded after a brief period of nurturing in a laboratory.
Primary Objectives:
To determine the rate of conversion to FDC following infusion of allogeneic CIK cells among
patients with MDS, therapy-related myeloid neoplasms, or MPD who receive non myeloablative
preparative regimen of TLI / ATG followed by allogeneic HCT and consolidation with allogeneic
CIK cells.
Secondary Objectives:
- To determine the 2 year overall survival (OS) and event free survival (EFS)
- To determine the incidence of acute GVHD following infusion of allogeneic CIK cells
- To assess the pre-transplant expression of NKG2D ligands in patients' bone marrow
aspirates.
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