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Clinical Trial Summary

This is a phase 1/2 study to evaluate the combination of vadastuximab talirine (SGN-CD33A; 33A) and azacitidine in subjects with previously untreated International Prognostic Scoring System (IPSS) Intermediate-2 or high risk myelodysplastic syndrome (MDS).


Clinical Trial Description

In the phase 1 portion of the study, escalating doses of 33A will be evaluated in combination with azacitidine, and a dose of 33A will be selected to proceed to phase 2. The phase 2 portion of the study is randomized, double-blind and placebo-controlled; it is designed to compare the overall response rate (ORR) between 2 study arms. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02706899
Study type Interventional
Source Seattle Genetics, Inc.
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date February 2016
Completion date November 6, 2017

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