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Mycobacterium Avium clinical trials

View clinical trials related to Mycobacterium Avium.

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NCT ID: NCT06266442 Recruiting - Clinical trials for Respiratory Tract Diseases

M. Avium WGS During Mav-PD Treatment

Start date: February 2024
Phase:
Study type: Observational

This is a prospective observational study using whole genome sequencing (WGS) to investigate whether new strains (other than the initially identified strain(s)) of M. avium are responsible for persistently culture positive sputum during treatment (refractory disease), or the reversion to culture positive sputum after prior conversion to negative. The study will further investigate for differences between participants living in the Toronto/York region versus participants living elsewhere. The primary goal of this prospective observational study is to understand why some patients with M. avium lung disease have persistent or recurrent M. avium in their sputum despite treatment. The aim is to understand whether it is usually due to treatment failure or new infection.

NCT ID: NCT02779049 Completed - Mycobacterium Avium Clinical Trials

Program Cell Death Receptor 1 in Mycobacterium Avium Complex Lung Disease

Start date: January 2015
Phase: N/A
Study type: Observational

1. To understand the components of PBMC in MAC-LD patients, including T cells, B cells, nature killer cells, and monocyte. 2. To confirm the phenomenon of reduced PBMC response in MAC-LD patients 3. To study the proportion of apoptosis and PD-1 expression in T cells among MAC-LD patients, MAC colonizers, patients with tuberculosis, and healthy controls. 4. To study the apoptosis and PD-1/PD-L1 expression in T cells/macrophage from bronchial lavage among MAC-LD patients, MAC colonizers, patients with tuberculosis, 5. To examine the PD-1 gene polymorphism and the correlation with MAC-LD.