Mycobacterium Avium Intracellulare Complex (MAC) Clinical Trial
Official title:
Pilot Study to Assess Safety and Efficacy of Short Course Multiple Drug Therapy for Adult Patients With Mycobacterium Avium Intracellulare Complex (MAC) Infection Associated With Mulit Focal Bronchiectasis and Multiple Small Nodules
This study is short course (3 month) multiple drug antibiotic therapy. The purpose of this research study is to evaluate the clinical and radiology response to assess whether drug resistance develops and assess quality of life measures with MAC disease.
The goal of this pilot study is to assess the safety and efficacy of short course (3 months)
multiple drug antimicrobial therapy in adults with MAC pulmonary disease associated with
multifocal bronchiectasis and multiple small nodules. We propose to evaluate the clinical
and radiographic response, assess whether macrolide (either Clarithromycin or Azithromycin)
resistance develops, and assess quality of life measures.
No evidence of efficacy is required to proceed to longer term studies; however, we will need
to confirm lack of development of macrolide resistance in this pilot study before proceeding
to any additional studies to evaluate the efficacy of short course MAC treatment.
Once we have demonstrated the feasibility of short course therapy and confirm that
resistance to macrolides does not develop, we hope to apply for external funding to support
a longer term randomized controlled trial comparing "standard" MAC therapy (which usually
consists of a period of eighteen to twenty-four months with at least three antimicrobials)
to short course (three months) MAC antimicrobial treatment, alternating each year with nine
months of non-MAC bronchial hygiene measures for two consecutive years. If a larger study
confirms efficacy of this approach, we would then propose even larger multi-site studies to
test the hypothesis that short course MAC therapy alternating every year with non-MAC
bronchial hygiene therapy should be considered in all adult patients with MAC pulmonary
disease associated with multifocal bronchiectasis and multiple small nodules throughout
their lives.
The longer term goal of this research is to develop an optimal treatment strategy for these
patients (in whom MAC will likely persist indefinitely) that will result in not only a
better quality of life, but less evidence of long term lung damage, less risk of
drug-related morbidity, and be better tolerated by the patients compared to current
treatment strategies.
The specific aims of this pilot study are as follows:
Primary Aim:
1. Confirm that macrolide (either Clarithromycin or Azithromycin) resistance does not
develop as a result of short course treatment.
Secondary Aims:
2. Assess for change in quality of life metrics (St. George Respiratory Questionnaire and
SF 12) from baseline to the conclusion of the study period (six months). We expect to
see improvement in quality of life measures as a result of this short course treatment
trial.
3. Assess for change in pulmonary function from baseline to the conclusion of the study
period. We expect to see improvement particularly in the FEV1, FEV1/FVC, and diffusing
capacity for carbon monoxide as a result of this short course treatment trial.
4. Assess for change in high resolution computerized tomography (HRCT) of the chest,
evidence of MAC pulmonary disease (multifocal bronchiectasis associated with multiple
small nodules) from baseline to the conclusion of the study period. We do not
anticipate being able to demonstrate improvement in the HRCT evidence of MAC lung
disease during the short period of this trial since these changes usually occur quite
slowly.
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Observational Model: Case-Only, Time Perspective: Prospective