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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT04632563
Other study ID # A095310
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date November 2020
Est. completion date August 2021

Study information

Verified date November 2020
Source Cambridge University Hospitals NHS Foundation Trust
Contact Benjamin Davies
Phone +44 1223 217551
Email bmd35@cam.ac.uk
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Musculoskeletal diseases, such as osteoarthritis, represent a large proportion of the global burden of disease with hip and knee osteoarthritis alone being the 11th greatest cause of disease burden. The purpose of this study is to determine the level of musculoskeletal symptoms in members of the Cambridge National Institute for Health Research (NIHR) BioResource and see if this is associated with their possession of genetic markers that have been identified as being associated with osteoarthritis. This will allow us to determine the real level of musculoskeletal symptoms in this large cohort of volunteers and provide basic information that could be used to facilitate further musculoskeletal research in the NIHR BioResource population.


Description:

All active members of the Cambridge NIHR BioResource will be approached. They will be sent an email outlining the purpose of the study and asking that if they would like to take part to please complete the online questionnaire which will be linked to in the email. For those individuals who agree to participate and complete the questionnaire, the Cambridge NIHR BioResource will provide the genetic marker information it already holds for specific markers that are known to be associated with osteoarthritis.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 5000
Est. completion date August 2021
Est. primary completion date April 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Member of the NIHR BioResource - Willing to consent to participate Exclusion Criteria: - Previous self-report of osteoarthritis on joining BioResource

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)
A questionnaire regarding musculoskeletal past medical history and current symptoms.

Locations

Country Name City State
n/a

Sponsors (2)

Lead Sponsor Collaborator
Cambridge University Hospitals NHS Foundation Trust University of Cambridge

Outcome

Type Measure Description Time frame Safety issue
Primary MSK Symptom Levels Musculoskeletal Symptoms in respondents 3 months
Primary Osteoarthritis genetic marker Possession (or not) of specific genetic markers for osteoarthritis (obtained from information already held by the NIHR BioResource) 6 months
Secondary MSK Cohort Identification of those with particular musculoskeletal injuries and conditions for future studies 6 months
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