Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource

Musculoskeletal Diseases Clinical Trial

Official title:

Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04632563
• Other study ID #: A095310
• Status: Not yet recruiting
• Start date: November 2020
• Est. completion date: August 2021

Study information

• Verified date: November 2020
• Source: Cambridge University Hospitals NHS Foundation Trust
• Contact: Benjamin Davies
• Phone: +44 1223 217551
• Email: bmd35[@]cam.ac.uk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Musculoskeletal diseases, such as osteoarthritis, represent a large proportion of the global burden of disease with hip and knee osteoarthritis alone being the 11th greatest cause of disease burden.

The purpose of this study is to determine the level of musculoskeletal symptoms in members of the Cambridge National Institute for Health Research (NIHR) BioResource and see if this is associated with their possession of genetic markers that have been identified as being associated with osteoarthritis.

This will allow us to determine the real level of musculoskeletal symptoms in this large cohort of volunteers and provide basic information that could be used to facilitate further musculoskeletal research in the NIHR BioResource population.

Description:

All active members of the Cambridge NIHR BioResource will be approached.

They will be sent an email outlining the purpose of the study and asking that if they would like to take part to please complete the online questionnaire which will be linked to in the email.

For those individuals who agree to participate and complete the questionnaire, the Cambridge NIHR BioResource will provide the genetic marker information it already holds for specific markers that are known to be associated with osteoarthritis.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 5000
• Est. completion date: August 2021
• Est. primary completion date: April 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Member of the NIHR BioResource

• Willing to consent to participate

Exclusion Criteria:

• Previous self-report of osteoarthritis on joining BioResource

Related Conditions & MeSH terms

• Musculoskeletal Diseases
• Musculoskeletal Injury

Intervention

Other:
• Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)
A questionnaire regarding musculoskeletal past medical history and current symptoms.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Cambridge University Hospitals NHS Foundation Trust	University of Cambridge

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MSK Symptom Levels	Musculoskeletal Symptoms in respondents	3 months
Primary	Osteoarthritis genetic marker	Possession (or not) of specific genetic markers for osteoarthritis (obtained from information already held by the NIHR BioResource)	6 months
Secondary	MSK Cohort	Identification of those with particular musculoskeletal injuries and conditions for future studies	6 months