Muscular Fatigue Clinical Trial
Official title:
A Randomized, Double-blind, Placebo Controlled Study to Investigate the Efficacy of Oleuropein on Skeletal Muscle Energy Metabolism and Fatigue in Humans
Preclinical studies performed at Nestlé Research (NR) identified oleuropein as a novel activator of mitochondrial calcium import. This potentiated mitochondrial calcium uptake resulted in decreased phosphorylation of the enzyme pyruvate dehydrogenase (PDH), which is linked to its activation as a rate limiting enzyme for mitochondrial oxidation, as well as increasing mitochondrial oxygen consumption, resulting ultimately in decreases in muscle fatigue. In addition, NR demonstrated that during aging, mitochondrial calcium and oxygen consumption rates are decreased in isolated skeletal muscle fibers. The next step in the evidence development is to demonstrate efficacy of oleuropein for improved muscle energy and decreased physical fatigue in a healthy aging population.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT00785811 -
Effect of Chronic Supplementation of L-arginine in the Muscular Performance
|
Phase 4 | |
| Completed |
NCT03902730 -
Leg Muscle Activity Measured Via Electromyography in Back Squat Variations
|
N/A | |
| Completed |
NCT04441840 -
Immune and Recovery Modulating Impact of Probiotic Supplementation After Intense Resistance Exercise
|
N/A |