Clinical Trials Logo

Clinical Trial Summary

The safety of guided practice of physical activity in myopathies is increasingly accepted, including muscular dystrophies. In facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophy, the aerobic training showed its physiological and functional efficiency without affecting the quality of life of patients. The issue of exercise therapy extended to all neuromuscular diseases, as has been rigorously analyzed, shows that the use of a training program combining endurance exercise targeted exercises and strength is even more relevant.

To complete the multidimensional assessments be managed by each team ( physiological assessments, functional tissue and quality of life) it is relevant to continue , for a descriptive study quantitative and qualitative analyzes by muscle imaging and spectroscopy (MRI and Nuclear Resonance Imaging (NMR) spectroscopy ).


Clinical Trial Description

These non-invasive assessments already in place at the time of the initial training (FSHD1 study, NCT01116570) will be repeated in the medium (12 months) and long term (30 months) in the same laboratory NMR AIM - CEA , Institute of Myology in Paris (P Carlier ). The data obtained from NMR repeated examinations and those obtained from biochemical analyzes and additional muscle histomorphometric (cellular aging estimation of involution fibroadipose ) on biopsies already programmed (initial, 6 months and 30 months, FSHD2 study, NCT01689480) will be respectively compared to initial time to follow the evolution food and energy capacity of trained muscles. The study of biopsies provide mechanistic arguments and morphometric specific cellular response to exercise, data will be advantageously complemented by NMR specialized examinations extended to all the muscles of the thigh (target of training ) and muscle quantification whole body MRI. ;


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01990976
Study type Observational
Source Centre Hospitalier Universitaire de Saint Etienne
Contact
Status Completed
Phase N/A
Start date May 2012
Completion date June 2015

See also
  Status Clinical Trial Phase
Recruiting NCT01834066 - Study Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Muscular Dystrophy. Phase 1/Phase 2
Recruiting NCT01834040 - Study Safety and Efficacy of BMMNC for the Patient With Duchenne Muscular Dystrophy Phase 1/Phase 2
Recruiting NCT00082108 - Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry
Recruiting NCT00138931 - Genetics of Cardiovascular and Neuromuscular Disease
Completed NCT00622453 - Arrhythmias in Myotonic Muscular Dystrophy N/A
Active, not recruiting NCT04038138 - Clinical Trial Readiness Network FSHD France: Prospective 24 Months MRI Study N/A
Completed NCT01451281 - Studying Skeletal Muscle, Heart, and Diaphragm Imaging in Boys With Duchenne Muscular Dystrophy
Not yet recruiting NCT05470478 - iBCI Optimization for Veterans With Paralysis N/A
Completed NCT04154098 - Evaluation of a Textile Scapula Orthosis N/A
Terminated NCT02653833 - The Study of Skeletal Muscle Blood Flow in Becker Muscular Dystrophy Early Phase 1
Not yet recruiting NCT06363526 - Effectiveness of 5-week Digital Respiratory Practice in a Group of Children With Duchenne Muscular Dystrophy and Becker Muscular Dystrophy. N/A
Completed NCT01393444 - ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis N/A
Recruiting NCT00912041 - BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia N/A
Completed NCT00866112 - A Randomized Exercise Trial for Wheelchair Users N/A
Completed NCT01882400 - Assessment of Response to Treatment of Osteoporosis With Oral Bisphosphonates in Patients With Muscular Dystrophy Phase 4
Recruiting NCT05726591 - Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders N/A
Completed NCT02815878 - Enhance Wellness for Individuals With Long-Term Physical Disabilities N/A
Completed NCT04035967 - Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities
Not yet recruiting NCT06290713 - Vasodilator and Exercise Study for DMD (VASO-REx) Phase 2
Recruiting NCT05230459 - A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1) Phase 1/Phase 2