Muscular Atrophy Clinical Trial
Official title:
Short-term Muscle Disuse Induces a Rapid and Sustained Decline in Daily Myofibrillar Protein Synthesis Rates
The effect of unilateral lower limb immobilisation over one week on muscle atrophy
This study aims to assess the effect of one week of unilateral leg immobilization on
quadriceps muscle volume and muscle protein synthesis rates. Participants wore a leg brace on
one leg and ambulated on crutches during the immobilization period. Thirteen healthy young
males were recruited to undertake this study.
It is currently understood that unilateral leg immobilization will result in a reduction in
muscle size (Berg et al., 1996, Wall et al., 2015) and muscle protein synthesis rates after a
period of disuse (de Boer et al., 2015, Glover et al., 2008). Recent research in this area
has shown that even short term periods of leg immobilization (i.e. <1 week) will result in
reductions in muscle size and muscle protein synthesis rates after the period of disuse (Wall
et al., 2015). However we currently do not have detailed information on how muscle disuse
affects muscle size and muscle protein synthesis over time during short term disuse (e.g. the
first week).
The stable isotope tracer deuterium oxide (D2O) will be applied to assess cumulative muscle
protein synthesis between days 0-2, 2-7 and 0-7 of the immobilization period in both the
immobilized and non immobilized legs. This will be in-conjunction with bilateral vastus
lateralis muscle biopsies before and after 2 and 7 days of immobilization. Furthremore,
quadriceps muscle volume was assessed via MRI scans that again occured before and after 2 and
7 days of immobilization. To gain a mechanistic insight on the molecular changes during
disuse a custom designed 48 well Taqman low density microarray genecard was applied to assess
the transcriptional response on genes involved in muscle protein synthesis and breakdown.
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