Clinical Trials Logo
  1. Home
  2. Muscular Atrophy
  3. NCT00835601

Resistive/Cardiovascular Training Study — CCD  

Muscular Atrophy Clinical Trial

Official title:
An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions

Clinical Trial Summary

This is a training study in healthy volunteers to characterize gains in lower-body resistive strength and cardiovascular capacity with exercise on a Combined Countermeasure Device (CCD) we have developed for the National Space Biomedical Research Institute. The CCD is a single platform which contains interchangeable modules for cardiovascular stepping exercises and lower body resistive exercises including squats, heel raises, abductor and adductor exercises and knee extension and flexion. The platform has the capability to tilt, yaw and pitch, and to translate in three dimensions in order to challenge the neurovestibular system. The underlying goal of the project is to provide a compact and efficient exercise modality that will prevent deterioration of the cardiovascular and musculoskeletal systems, and the neurovestibular system, in long-duration spaceflights. The goal of the current study is simply to test the hypothesis that in healthy volunteers, the exercise prescription proposed for the device will improve strength and VO2 max. Subjects are tested for lower body resistive strength and V02max at baseline, then are trained for 12 weeks, and tested again at followup to test for a change. 36 subjects, allowing for a 20% attrition rate, allows sufficient power to detect 95% percent confidence intervals in the changes in the strength and V02max measures of roughly 10-20%. If we observe gains in these indices which are similar to those reported in the literature for simultaneous cardiovascular and resistive strength protocols, then we believe that there is sufficient evidence to test CCD in a bedrest model of long-duration spaceflight.

Clinical Trial Description

n/a

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00835601
Study type Observational
Source University of California, San Francisco
Contact
Status Completed
Phase N/A
Start date January 2009
Completion date May 2011
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02912130 - Exercise and Nutrition Interventions in Age-related Sarcopenia N/A
Completed NCT01344135 - Nutritional Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Muscle Atrophy N/A
Completed NCT04147741 - Effects of a Pre-Workout on Performance, Perceptual Responses, Energy Feelings and Muscular Properties, After a Training Microcycle in Adults. N/A
Active, not recruiting NCT01872741 - Minipterional Versus Pterional Craniotomy N/A
Active, not recruiting NCT03540732 - Feeding With Indirect Calorimetry and Cycling in the Elderly N/A
Not yet recruiting NCT02568020 - LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD Phase 4
Completed NCT01820702 - Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation N/A
Completed NCT00787098 - Investigating Modes of Progressive Mobility Phase 2
Completed NCT02555670 - Relation Between Bioelectrical Impedance Analysis (BIA) and CT-scan Analysis in the ICU N/A
Recruiting NCT04067167 - Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant Diseases N/A
Not yet recruiting NCT05769088 - Effects of a Multi-Ingredient Pre-Workout Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing in Adults. N/A
Recruiting NCT06053229 - Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization N/A
Not yet recruiting NCT01373697 - Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel Phase 3
Recruiting NCT05481346 - Effects of Multidomain Training of Health With Aging (Train-Old) N/A
Completed NCT02495727 - Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men N/A
Completed NCT01369511 - A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement Phase 2
Completed NCT02984332 - Timecourse of Immobilization Experiment N/A
Completed NCT02566590 - Preventing the Loss of Muscle and Function in Hospitalized Older Adults N/A
Completed NCT02034942 - Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on Physical Function N/A
Completed NCT01788111 - Occurrence, Diagnosis and Treatment of Neck and Back Pain in Helicopter Pilots. N/A