Muscle Weakness Clinical Trial
Official title:
Effects of Unloading and Sleep Restriction on Balance Regulation and Quadriceps Structure and Contractile Function
The goal of this trial is to learn about how restricted sleep and not bearing weight on the leg affects muscle strength and posture control. Participants will walk exclusively on one leg, sleep at differing intervals, and complete posture tests, muscle strength tests, and muscle imaging. Researchers will compare adequate sleep and restricted sleep to see if muscle strength and posture are affected.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Age between 18 and 50 years - Regularly engaging in aerobic exercise (> 150min/wk) and resistance exercise (>1 time per week) for the past 12 months - Regularly sleep at least 7 hours per night Exclusion Criteria: - Age < 18 or > 50 years - Height between <150 (F) or <170 (M) and > 190 cm (both sexes) - Waist circumference < 55cm or > 90cm (F) and < 75cm or > 100cm (M) - Body mass index < 18.5 or > 27.5 - Do not regularly sleep between 7 and 9 hours each night - Have a known sleep disorder - Not regularly engaging in exercise for previous 12 months - Blood clotting disorder - Heart arrhythmia - Implanted device which could negatively be affected by electrical impulse or strong magnetic field such as pacemaker, internal defibrillator, or cochlear implant - Diagnosed cardiovascular, pulmonary, renal, or metabolic disease - Pregnancy (within previous 6 months) - Oral contraceptive use (within previous three months) - High resting blood pressure (>140 systolic and/or > 90 diastolic) - Currently or previously undergone gender-affirming therapy (hormone therapy or sexual reassignment surgery) - Low back or leg injury in previous 6 months - Currently taking medication to assist with sleep - Muscle, bone, or joint injury that limits physical activity within previous 6 months - Neurological disorder which affects balance (such as multiple sclerosis or Parkinson's disease) |
Country | Name | City | State |
---|---|---|---|
United States | University of Kentucky | Lexington | Kentucky |
Lead Sponsor | Collaborator |
---|---|
Lance Bollinger | National Aeronautics and Space Administration (NASA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Interpolated Twitch | Subjects will sit upright in an isokinetic dynamometer with the knee at 60° flexion. Gel electrode pads will be placed over the femoral nerve and just proximal to the patellar tendon. Square wave, constant current, doublet pulses from an electrical stimulator will be used to evoke twitches prior to, during, and following a maximal voluntary isometric contraction (MVIC). | Baseline and study completion, approximately 14 days | |
Primary | Change in Single Leg Stand (SLS) | Balance will be assessed using a dual force plate system. Participants will be asked to stand on one leg and maintain their balance for 15 seconds | Baseline and study completion, approximately 14 days | |
Primary | Muscle volume | Diffusion Tensor Imaging (DTI) will be used to quantify muscle volume. Subjects will lay supine, and slightly flex the knee (~10°) to elongate and straighten the quadriceps. A spine array coil will be placed on the MR-scanner table and a flexible body coil wrapped around the upper thigh and centered over mid-thigh of the dominant leg. Multiple images will be taken. DSI Studio program will be used to analyze raw images. | Post-intervention, approximately 14 days after start of study | |
Primary | Change in Single Leg Land and Hold | Balance will be assessed using a dual force plate system. Participants will step off a wooden platform and land with one leg only in the middle of the respective force plate. As soon as the participant lands, they will be asked to maintain their position for 10 seconds. | Baseline and study completion, approximately 14 days |
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