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Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients

Weaning Failure Clinical Trial

Official title:
Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients

Clinical Trial Summary

Levosimendan is a relatively new drug that improves cardiac contractility in patients with heart failure. Its main mechanism of action is enhanced binding of calcium to the myocardial contractile proteins. Recent data from our lab showed that levosimendan improves contractility of human diaphragm in vitro (muscle fibers from COPD patient diaphragm) and in vivo (healthy subjects). Accordingly, levosimendan may appear of value in the treatment of disorders associated with impaired respiratory muscle function, such as mechanically ventilated patients.We hypothesize that levosimendan could improve respiratory muscle function in mechanically ventilated patients commencing a CPAP trial.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01721434
Study type Interventional
Source University Medical Center Nijmegen
Contact Leo MA Heunks, MD, PhD
Phone 024-3617273
Email l.heunks@ic.umcn.nl
Status Recruiting
Phase Phase 2/Phase 3
Start date September 2012
Completion date May 2016
View Details
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