Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

Muscle Soreness Clinical Trial

— PRSRE  

Official title:

Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03540602
• Other study ID #: Polyphenol Supplementation
• Status: Recruiting
• Phase: Phase 1
• Start date: May 1, 2018
• Est. completion date: August 2018

Study information

• Verified date: May 2018
• Source: Jacksonville University
• Contact: Heather Hausenblaus
• Phone: 904-256-7975
• Email: hhausen[@]ju.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. The strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. As the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. Thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. Where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. This concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. The purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: August 2018
• Est. primary completion date: August 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 21 Years to 45 Years

Eligibility

Inclusion Criteria:

• 6 months of resistance training experience with barbel back squat exercise

Exclusion Criteria:

• Not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.

Related Conditions & MeSH terms

• Muscle Soreness
• Myalgia

Intervention

Dietary Supplement:
• Tart Cherry
NordicCherry Tart Cherry Extract Powder 500 mg from Specnova, inc

Other:
• Placebo Oral Capsule [CEBOCAP]
Rice flour

Locations

Country	Name	City	State
United States	Jacksonville University	Jacksonville	Florida

Sponsors (2)

Lead Sponsor	Collaborator
Jacksonville University	Specnova, inc

Country where clinical trial is conducted

United States, 

References & Publications (4)

Alessio HM, Goldfarb AH, Cutler RG. MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. Am J Physiol. 1988 Dec;255(6 Pt 1):C874-7. — View Citation

Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S379-99; discussion S419-20. Review. — View Citation

Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008 Oct;88(4):1243-76. doi: 10.1152/physrev.00031.2007. Review. — View Citation

Reid MB. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol (1985). 2001 Feb;90(2):724-31. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment of Oxidative Stress	Blood analyses will be used, 8 mL of blood will be taken from the participant six times per condition. The blood will be centrifuged to separate the serum/ plasma and analyzed by enzyme- linked immunosorbent assay (ELISA) for c- reactive protein and creatine kinase, and oxidative damage	7 weeks
Secondary	Muscle soreness	Subjects will mark a line on a 10cm scale that corresponds to the amount of muscular soreness they currently perceive	7 weeks
Secondary	Vertical Jump Performance	Subjects will be instructed to stand on a NeuroCom Balance Manager forceplate with hands on hips. Subjects will then be instructed to perform 3 consecutive vertical jumps, as high as possible with minimal time between jumps. The jumps will later be assessed for power production.	7 weeks