Muscle Injury Clinical Trial
Official title:
Investigation of The Efficiency of Pulsed Electromagnetic Field Treatment and Stretching Exercise In Experimental Skeletal Muscle Injury Model
Verified date | August 2023 |
Source | Suleyman Demirel University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time. In the study, animals were divided into 5 groups (Control, INJ, INJ+Exercise, INJ+PEMF, INJ+Exercise+PEMF). Experimental animals were sacrificed on the 7th and 14th days to see the effects of the treatments. At the end of the experiment, genetic, histopathological, and immunohistochemical evaluations were made in the muscle tissue.
Status | Completed |
Enrollment | 64 |
Est. completion date | November 7, 2022 |
Est. primary completion date | October 2, 2022 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 10 Months to 11 Months |
Eligibility | Inclusion Criteria: - Healthy young wistar albino rats Exclusion Criteria: - not having any injury |
Country | Name | City | State |
---|---|---|---|
Turkey | SuleymanDU | Isparta |
Lead Sponsor | Collaborator |
---|---|
Suleyman Demirel University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mononuclear cell infiltration, Atrophy and necrosis, Pyknotic nucleus assesment at the end of two weeks | hematoxylin-eosin staining | two week | |
Primary | VEGF and FGF assesment at the end of two weeks | immunohischemical staining | two week | |
Primary | TGF-ß1, eNOS assesment at the end of two weeks | Quantitative Reverse-Transcriptase Polymerase Chain Reaction (RT-qPCR) | two week |
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