Clinical Trials Logo

Clinical Trial Summary

Patients in rehabilitation may undergo periods of prolonged limb immobilization in response to injury, surgery, or illness. Due to disuse, the size and strength of muscles controlling the affected limb can decrease significantly, possibly resulting in physical impairment or lower quality of life during the recovery phase. Prior immobilization studies have shown that the rate and degree of decline in muscle strength exceeds that of muscle size, indicating that determinants of muscle strength unrelated to muscle size may further contribute to functional changes during immobilization. The purpose of this study is to describe the changes in muscle strength, muscle size, corticospinal excitability, voluntary activation, M1 cortical thickness, and resting state functional connectivity following a 2-week limb immobilization period in young women.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05115643
Study type Interventional
Source McGill University
Contact Tyler Churchward-Venne, PhD
Phone (514) 398-4148
Email [email protected]
Status Recruiting
Phase N/A
Start date November 2021
Completion date August 2022

See also
  Status Clinical Trial Phase
Not yet recruiting NCT03662555 - Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function N/A
Completed NCT00060970 - Evaluating Muscle Function After Ankle Surgery N/A
Completed NCT03797781 - Protein Ingestion and Skeletal Muscle Atrophy N/A
Completed NCT03299972 - Multidisciplinary Research Into the Effects of Resistance Exercise and Whey Protein Supplementation in Healthy Older Men N/A
Recruiting NCT05072652 - Short Term Immobilization of the Lower Limb N/A
Recruiting NCT04199936 - Postoperative Electrical Muscle Stimulation (POEMS) N/A
Not yet recruiting NCT04772040 - Impact of Fish Oil Dose on Tissue Content and Function N/A
Enrolling by invitation NCT04456530 - Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study Phase 2/Phase 3
Recruiting NCT03551990 - Influence of Motor Proteins on Muscle Atrophy in Cancer Patients N/A
Recruiting NCT04900701 - The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults. N/A
Withdrawn NCT03069781 - The Effects of 17β-estradiol on Skeletal Muscle Early Phase 1
Recruiting NCT02221804 - The Effect of Two Weeks of Voluntary Reduced Physical Activity in Chronic Obstructive Pulmonary Disease (COPD) N/A
Completed NCT01991171 - Effectiveness of the Kinesio Taping® in Muscle Activation N/A
Active, not recruiting NCT01470950 - Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy N/A
Active, not recruiting NCT03153826 - Determinants of Lower Limb Muscle Atrophy Induced During an Hospitalization for Exacerbation of COPD N/A
Completed NCT03046095 - The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation N/A
Recruiting NCT04753450 - Correlation of Muscle Ultrasound Measures (2D and 3D) With Biphotonic X-ray Absorptiometry in Oldest Old Patients.
Enrolling by invitation NCT03819660 - Long Term Safety of Amifampridine Phosphate in Spinal Muscular Atrophy 3 Phase 2
Recruiting NCT04849624 - Body Composition Study in Critically Ill Patients-Extended to COVID-19
Completed NCT03195348 - The Effects of Whole Body Unloading on Physiological Function N/A