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Clinical Trial Summary

Patients in rehabilitation may undergo periods of prolonged limb immobilization in response to injury, surgery, or illness. Due to disuse, the size and strength of muscles controlling the affected limb can decrease significantly, possibly resulting in physical impairment or lower quality of life during the recovery phase. Prior immobilization studies have shown that the rate and degree of decline in muscle strength exceeds that of muscle size, indicating that determinants of muscle strength unrelated to muscle size may further contribute to functional changes during immobilization. The purpose of this study is to describe the changes in muscle strength, muscle size, corticospinal excitability, voluntary activation, M1 cortical thickness, and resting state functional connectivity following a 2-week limb immobilization period in young women.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05115643
Study type Interventional
Source McGill University
Contact Tyler Churchward-Venne, PhD
Phone (514) 398-4148
Email [email protected]
Status Recruiting
Phase N/A
Start date November 2021
Completion date August 2022

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