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Postoperative Electrical Muscle Stimulation (POEMS) — POEMS  

Postoperative Complications Clinical Trial

Official title:
Postoperative Electrical Muscle Stimulation (POEMS) to Attenuate Muscle Atrophy

Clinical Trial Summary

Patients lose a significant amount of muscle following major abdominal surgery. This is partly due to a catabolic response to the surgical insult and inflammation, but is also probably due to a lack of muscle use secondary to immobility. This study will aim to assess whether some or even all of postoperative muscle loss in the upper leg muscle group is preventable through electrical muscle stimulation to mimic physical activity.

Clinical Trial Description

Following major gastrointestinal surgery patients may loose around 6 % of their skeletal muscle mass in the first 5 days. Whilst some of this loss is as a result of inflammation and starvation, some is due to muscle disuse. Studies have shown that patients spend 96% of their time being sedentary in the first 5 days following major abdominal surgery and by day 5 are still taking a median of less than 500 steps per day. Studies of healthy volunteers who undergo similar muscle disuse loose approximately 3.5% of skeletal muscle mass over the same time period, indicating that around half of postoperative muscle loss may be due to immobility. Through the use of electrical muscle stimulation, this study will aim to mimic high levels of exercise in the quadriceps of patients who have undergo major gastrointestinal surgery to see whether this reduces or prevents muscle loss. Patients muscles will be measured using ultrasound and DXA and neuromuscular function will be measured using electromyography. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04199936
Study type Interventional
Source University of Nottingham
Contact Edward J Hardy, MBBCh
Phone 07890429460
Email edward.hardy@nhs.net
Status Recruiting
Phase N/A
Start date November 18, 2020
Completion date August 1, 2021
View Details
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