Multiple Trauma Clinical Trial
Official title:
Central Venous-arterial Carbon Dioxide Pressure Difference in Correlation to Dynamic Changes of Serum Lactate as an Indicator of Tissue Perfusion in Polytruama Patients
Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial and venous CO2, oxygen tension or content as indicators for tissue perfusion.
Poly trauma patients have high incidence of mortality and morbidity in spite of improvements
and advances in facilities. However, no doubt that early resuscitation and interventions
make a big difference upon the overall outcome.
A lot of methods, indices, laboratory and biomarkers have been utilized to evaluate the
progress and quality of resuscitation and the early hospital interventions in such group of
critically ill patients including central venous pressures, urine output, mixed venous
oxygen saturation, and gastric tonometry. Most of recent means focus upon the regional
tissue perfusion rather than global, however some researches have tried the difference
between arterial and venous CO2,oxygen tension or content ( Pv -a co2& Pa -v O2 ) in
addition to dynamic changes in lactate(3) as predictors for tissue perfusion in sepsis
patients after establishment of sepsis campaign (bundle).
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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