Synapse Alterations in MSA Patients

Status Completed

Clinical Trial Summary

Synaptic loss has been implicated in various neurodegenerative conditions, yet its understanding in multiple system atrophy (MSA) remains limited. The aim of this study was to examine spatial synaptic density alterations in MSA patients and evaluate the potential of [18F]SynVesT-1 PET as an imaging biomarker for MSA in both diagnosis and monitoring disease severity.

Clinical Trial Description

60 MSA patients (30 MSA-P subtype and 30 MSA-C subtype) and 30 age-matched healthy controls (HCs) underwent [18F]SynVesT-1 PET/CT for synaptic density assessment. Visual, voxel, and volumetric region-of-interest (VOI) analyses were employed to elucidate synaptic density patterns in the MSA brain and establish visual diagnostic criteria. VOI-based computer-assisted analyses were utilized to develop diagnostic models for MSA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06221644
Study type	Observational
Source	Xiangya Hospital of Central South University
Contact
Status	Completed
Phase
Start date	April 1, 2022
Completion date	November 25, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03593512` - Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy	N/A
Recruiting	`NCT03648905` - Clinical Laboratory Evaluation of Chronic Autonomic Failure
Active, not recruiting	`NCT05699460` - Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
Recruiting	`NCT02897063` - Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure	Phase 1
Not yet recruiting	`NCT00758849` - Fipamezole in Neurogenic Orthostatic Hypotension	Phase 2
Completed	`NCT01155492` - Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease	N/A
Recruiting	`NCT04431713` - Exenatide Once-weekly as a Treatment for Multiple System Atrophy	Phase 2
Completed	`NCT04184063` - Study of NBMI Treatment in Patients With Atypical Parkinsons (PSP or MSA)	Phase 2
Recruiting	`NCT05121012` - Synaptic Loss in Multiple System Atrophy
Terminated	`NCT03589976` - A Futility Trial of Sirolimus in Multiple System Atrophy	Phase 2
Recruiting	`NCT04706234` - Systematic Assessment of Laryngopharyngeal Function in Patients With MSA, PD, and 4repeat Tauopathies
Completed	`NCT00368199` - Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes	N/A
Recruiting	`NCT04472130` - Neurodegenerative Diseases Registry
Recruiting	`NCT04876326` - Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy	N/A
Recruiting	`NCT04680065` - GDNF Gene Therapy for Multiple System Atrophy	Phase 1
Completed	`NCT03753763` - Safinamide for Multiple System Atrophy (MSA)	Phase 2
Recruiting	`NCT04250493` - Insulin Resistance in Multiple System Atrophy	N/A
Recruiting	`NCT06072105` - Medical Decision Making in Multiple System Atrophy	N/A
Terminated	`NCT02149901` - Water and Sudafed in Autonomic Failure	Early Phase 1
Terminated	`NCT00997672` - Lithium in Multiple System Atrophy	Phase 2