Synapse Alterations in MSA Patients

Status Completed

Clinical Trial Summary

Synaptic loss has been implicated in various neurodegenerative conditions, yet its understanding in multiple system atrophy (MSA) remains limited. The aim of this study was to examine spatial synaptic density alterations in MSA patients and evaluate the potential of [18F]SynVesT-1 PET as an imaging biomarker for MSA in both diagnosis and monitoring disease severity.

Clinical Trial Description

60 MSA patients (30 MSA-P subtype and 30 MSA-C subtype) and 30 age-matched healthy controls (HCs) underwent [18F]SynVesT-1 PET/CT for synaptic density assessment. Visual, voxel, and volumetric region-of-interest (VOI) analyses were employed to elucidate synaptic density patterns in the MSA brain and establish visual diagnostic criteria. VOI-based computer-assisted analyses were utilized to develop diagnostic models for MSA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06221644
Study type	Observational
Source	Xiangya Hospital of Central South University
Contact
Status	Completed
Phase
Start date	April 1, 2022
Completion date	November 25, 2022

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