Cognitive Impairement In Frontotemporal Dementia

Multiple System Atrophy Clinical Trial

Official title:

Cognitive Impairement In Frontotemporal Dementia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03452956
• Other study ID #: 298201
• Status: Completed
• Start date: July 1, 2003
• Est. completion date: July 15, 2020

Study information

• Verified date: November 2020
• Source: University of Pennsylvania
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.

Description:

Comparative and longitudinal studies reveal clinical differences between subgroups of patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA), Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC), and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy and fMRI studies show correlated neural defects in FTD subgroups. The investigators will obtain converging evidence from multiple sources to test hypotheses about the neural basis for cognitive functions such as semantic memory, grammatical processing, and social functioning in these FTD subgroups, while improving clinical care for these patients. Recent studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. The investigators will obtain comparable neuropsychological and biomarker data in order to compare these patient groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 997
• Est. completion date: July 15, 2020
• Est. primary completion date: July 15, 2020
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Individuals who have been diagnosed with FTD, PSP, and MSA

Exclusion Criteria:

• Individuals under 18 years of age

• People with pacemakers or certain metallic implants

• pregnant women

Related Conditions & MeSH terms

• Aphasia, Primary Progressive
• Dementia
• Frontotemporal Degeneration
• Frontotemporal Dementia
• Multiple System Atrophy
• Pick Disease of the Brain
• Progressive Supranuclear Palsy
• Shy-Drager Syndrome
• Supranuclear Palsy, Progressive

Intervention

Other:
• None-Observation Only
No intervention-this is an observational study

Locations

Country	Name	City	State
United States	University of Pennsylvania	Philadelphia	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
University of Pennsylvania

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Effortful speech in Progressive Nonfluent Aphasia (PNFA)	Speech samples related to cortical atrophy seen on MRI and fMRI studies of verb past tense inflection.	This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Other	Social disinhibition and rule violation in FTD	Relationship of cognitive testing and MRI data and changes over time.	This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Primary	Progression	Changes over time in MRI and cognitive testing data.	This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Secondary	Impaired semantic memory in Semantic Dementia (SD).	The impact of cortical atrophy on language processing.	This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed