Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients

Status Completed

Clinical Trial Summary

Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a Immune function. In this trial intensive care unit patients with enteral feeding will receive either enteral glutamine or maltodextrin as placebo for 28 days.

Clinical Trial Description

A randomized, double blind, controlled trial will be conducted in general intensive care unit (ICU) in Tehran, Iran. After a full review of the inclusion and exclusion criteria and explanation of the risks and benefits of the study, written consent form will be completed. The participants are 200 eligible hospitalized patients with enteral feeding in ICU, aged ≥ 18 years. Intervention patients will be received 0.3 g/kg/day of glutamine along with enteral formula for 28 days and control patients will be received maltodextrin along with enteral formula for 28 days. Patients will be evaluated for occurrence of new infection, organ failure, duration of stay in ICU, 28 days and 6 months mortality and inflammatory and immune markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02998931
Study type	Interventional
Source	Shahid Beheshti University
Contact
Status	Completed
Phase	Phase 3
Start date	November 10, 2016
Completion date	September 10, 2018

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