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Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies

Multiple Myeloma Clinical Trial

Official title:
Phase I Study of Dasatinib in Recipients of Allogeneic Stem Cell Transplantation for Hematologic Malignancies.

Clinical Trial Summary

This study uses a drug called dasatinib to produce an anti-cancer effect called large granular lymphocyte cellular expansion. Large granular lymphocytes are blood cells known as natural killer cells that remove cancer cells. Researchers think that dasatinib may cause large granular lymphocyte expansion to happen in patients who have received a blood stem cell transplant (SCT) between 3 to 15 months after the SCT. In this research study, researchers want to find how well dasatinib can be tolerated, the best dose to take of dasatinib and how to estimate how often large granular lymphocytic cellular expansion happens at the best dose of dasatinib.

Clinical Trial Description

This is a phase I, dose-escalation study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01643603
Study type Interventional
Source Barbara Ann Karmanos Cancer Institute
Contact
Status Terminated
Phase Phase 1
Start date May 2012
Completion date October 9, 2018
View Details
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