Multiple Myeloma and Plasma Cell Neoplasm Clinical Trial
Official title:
Phase II Study of Arsenic Trioxide in Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of arsenic trioxide in treating patients
who have relapsed or refractory stage II or stage III multiple myeloma.
OBJECTIVES: I. Determine the response rate of patients with relapsed or refractory stage II
or III multiple myeloma treated with arsenic trioxide. II. Determine the overall and
relapse-free survival rates of patients treated with this drug. III. Determine the safety
profile of this drug in these patients.
OUTLINE: Patients receive arsenic trioxide IV on days 1-5 and 8-12. Treatment repeats every 4
weeks for up to 6 courses. Patients are followed at 4 weeks after the last treatment dose.
PROJECTED ACCRUAL: A total of 55 patients will be accrued for this study.
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