MRI Clinical Trial
Official title:
7.0T Magnetic Resonance Imaging Study of Parkinson's Disease
This clinical trial study is conducted to detect the imaging characteristics of the patients with Parkinson's diseases (PD) by 7-Tesla (7T) magnetic resonance imaging (MRI).
Status | Recruiting |
Enrollment | 200 |
Est. completion date | July 1, 2030 |
Est. primary completion date | July 1, 2027 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - the patients with PD who was diagnosed by the experienced neurologist specializing in movement disorders Exclusion Criteria: - the patients with brain disorders such as cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease; - psychiatric disorders with impaired cognitive function; - contraindications to MRI. |
Country | Name | City | State |
---|---|---|---|
China | Chinese PLA General Hospital | Beijing | Beijing, China |
Lead Sponsor | Collaborator |
---|---|
Chinese PLA General Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The change in motor symptoms in PD patients. | The patient's clinical state was evaluated according to the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) and H-Y scale. The former scale total score ranges from 0 to 199, with higher scores indicating more severe symptoms in patients. H-Y scale categorizes PD into five stages with higher stages indicate more severe symptoms.
Comparison will be performed from examinations for case-control study versus for baseline and 5-year follow-up timepoints. |
5 year after the conduction of clinical trial | |
Secondary | Functional connectivity alterations between individuals with different subtypes of PD and healthy subjects. | The functional connectivity calculation is primarily based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions, reflecting the functional activity of the brain. A higher value indicates stronger connectivity and more active function. | 5 year after the conduction of clinical trial | |
Secondary | Structural connectivity alterations between individuals with different subtypes of PD and healthy subjects. | The structural connectivity calculation is primarily based on the DTI sequence, which is used to describe the connectivity of white matter fiber bundles between different brain regions. A higher value indicates stronger connectivity. | 5 year after the conduction of clinical trial | |
Secondary | Clinical variables spectrum features linking to the motor symptoms and imaging spectrum features. | Medical records and test data of patients, including demographic characteristics, motor scores, non-motor scores, common comorbidity, hematological analysis, coagulation function, lipids profile, blood biochemistry, were used to construct clinical variables spectrum features. The distribution characteristics of motor symptoms and imaging spectrum features were compared with the multi-dimensional matrix. | 5 year after the conduction of clinical trial |
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