MRI Clinical Trial
Official title:
Noninvasive Imaging of Heart Failure
Background:
- Heart failure is a common cardiovascular disorder whose incidence increases with age,
affecting up to 10% of people older than 65 years of age. As the population ages, the
prevalence and cost of heart failure will continue to rise. Researchers are interested in
using noninvasive imaging methods to better understand the symptoms and effects of heart
failure.
Objectives:
- To conduct a noninvasive comparative imaging study of individuals with heart failure.
Eligibility:
- Individuals at least 18 years of age who have been diagnosed with heart failure (with at
least mild symptoms and slight limitations on physical activity).
Design:
- This study will last approximately 2 years and will require four visits to the National
Institutes of Health Clinical Center, with one screening visit and three study visits.
- Participants will be screened with a full medical history and physical examination, as
well as blood and urine samples.
- Participants will have the following tests during each study visit:
- Physical examination
- Blood and urine samples
- Cardiac magnetic resonance imaging
- Cardiac computerized tomography to study the blood vessels in and leading to the heart
- Echocardiogram to evaluate heart function
- Electrocardiogram to measure heart electrical activity
- The three study visits will take place 1 year apart. Participants will also receive
follow-up phone calls 6 months after the first and second visits.
- No treatment will be provided as part of this protocol.
More than 9% of American men and close to 5% of women ages 60 to 79 years report a diagnosis of heart failure, where above the age of 80 years these figures increase to 13.8% and 12.2%, respectively. Projection into the middle part of this century suggests that, as the population ages, the prevalence and cost of heart failure will continue to rise. The primary aim of this proposal is to investigate noninvasive imaging methods for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMR) in heart failure patients. The secondary aims are to investigate the association between diffuse fibrosis detected by CMR with left ventricular function, and examine the utility of multi-detector CT (MDCT) in detecting diffusion myocardial fibrosis. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05036629 -
Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects
|
N/A | |
| Completed |
NCT02548819 -
University Hospital Cardiac Device MR Registry: The Safety of MR Imaging in Patients With Implanted Cardiac Devices
|
N/A | |
| Completed |
NCT01168479 -
FLAME: Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer
|
Phase 3 | |
| Completed |
NCT00512226 -
Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia
|
N/A | |
| Recruiting |
NCT05439330 -
Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning
|
N/A | |
| Not yet recruiting |
NCT05464576 -
Tumor Staging T of Bladder Tumours: Correlation of MRI and Anatomopathologic Analysis
|
N/A | |
| Recruiting |
NCT04028375 -
Study of CT and MR in the Gastric Cancer
|
||
| Recruiting |
NCT04034667 -
Study of CT and MR in the Lung Cancer
|
||
| Recruiting |
NCT04231175 -
Dedicated MR Imaging vs Surgical Staging of Peritoneal Carcinomatosis in Colorectal Cancer
|
N/A | |
| Completed |
NCT00949507 -
Comparison of Two Regimens of Anesthesia for Children Undergoing Magnetic Resonance Imaging (MRI) in General Anesthesia
|
Phase 4 | |
| Completed |
NCT01420211 -
Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05167669 -
Pain Relief in Symptomatic Bone Metastases With Adjuvant Hyperthermia MR Guided HIFU
|
Early Phase 1 | |
| Recruiting |
NCT05618990 -
OPTIMIZATION of ADVANCED MR SEQUENCES
|
||
| Recruiting |
NCT05107232 -
OSV-IRM - Volunteer MRI Sequence Optimization
|
N/A | |
| Completed |
NCT00556101 -
Patient Acceptance of Whole Body Magnetic Resonance Angiography
|
N/A | |
| Recruiting |
NCT03142698 -
Evaluation of 4 MRI Methods (PDFF 3, 6 and 11 Gradient Echoes and Spectroscopy) Compared to the Reference Method (Liver Biopsy) in Quantification of Hepatic Steatosis
|
N/A | |
| Suspended |
NCT00554073 -
Whole Body Magnetic Resonance Angiography in Ischemic Patients at 1.5 and 3T
|
N/A | |
| Completed |
NCT06366906 -
10-year Retrospective Study of Oral and Maxillofacial Squamous Cell Carcinoma
|
||
| Not yet recruiting |
NCT05359497 -
Value of MRCP+ And Liver Multiscan in the Management of Dominant Strictures in Primary Sclerosing Cholangitis
|
N/A | |
| Recruiting |
NCT05192629 -
Intranasal Dexmedetomidine Versus Oral Midazolam as Premedication for Propofol Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging
|
Phase 3 |