Genetics of Motor Learning

Status Terminated

Clinical Trial Summary

Background:

- New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with related studies taking place in the Human Motor Control Section of the National Institute of Neurological Diseases and Stroke (NINDS). Participants in motor learning studies conducted at NINDS will be asked to provide blood samples for further evaluation.

Objectives:

- To create a repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies.

Eligibility:

- Individuals between 18 and 100 years of age who are or will be participating in motor learning research studies at the National Institutes of Health.

Design:

- Blood draws for genetic testing will usually be done on the same day as the motor learning study. Participants will provide one blood sample for research.

- No treatment will be provided under this study....

Clinical Trial Description

OBJECTIVE:<TAB>

The objective of this study is to create a bio-repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies. Blood will be analyzed for BDNF and samples stored for future genetic studies. . A variety of genes that may affect motor learning are being increasingly identified, and variations among these genes, referred to as polymorphisms, may help explain individual differences.

STUDY POPULATION: <TAB>

We will enroll up to five hundred healthy volunteers and five hundred volunteers with movement difficulties who are between the ages of 18 and 100 and who are already participating, or will be participating, in other protocols dealing with motor learning research studies at the National Institutes of Health (NIH).

DESIGN:<TAB>

This is an observational and repository protocol that involves a single blood sample for genetic analysis. This will allow the genetic characterization of subjects participating in motor learning protocols to be analyzed and tested for the role of genetics in motor learning results.

OUTCOME MEASURE:

We will compare genetic variations with the different behavioral, electrophysiologic, imaging, or other outcomes acquired in the associated motor learning studies. Thus, we will determine whether specific polymorphisms are associated with different measures of motor learning. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01105845
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact
Status	Terminated
Phase
Start date	April 14, 2010
Completion date	December 21, 2015

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT05623644` - Multimodal MR Imaging Study on ET and PD Patients Subjected With MRgFUS Thalamotomy
Active, not recruiting	`NCT03548779` - North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2	N/A
Completed	`NCT03295786` - Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease	Phase 1/Phase 2
Completed	`NCT03722212` - Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test	N/A
Recruiting	`NCT05973929` - Movement Disorders in Multiple Sclerosis Patients
Terminated	`NCT02823158` - Bilateral Pallidal Stimulation in Patients With Advanced Parkinson's Disease-LATESTIM	N/A
Enrolling by invitation	`NCT01210781` - Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation
Enrolling by invitation	`NCT00355927` - Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.	N/A
Completed	`NCT00037167` - Effects of Exercise Poles on Older Adults During Exercise Walking	Phase 1/Phase 2
Recruiting	`NCT04784494` - MST for Parkinson's Disease	N/A
Terminated	`NCT03270189` - Effect of the Visual Information Change in Functional Dystonia	N/A
Recruiting	`NCT04061135` - Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders	N/A
Recruiting	`NCT04176692` - The Effects of Muscle Characteristics on the Control of Shoulder Complex During Functional Movements
Suspended	`NCT04912115` - Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia	Phase 2
Completed	`NCT00500994` - Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures	Early Phase 1
Completed	`NCT04536987` - Robot Therapy for Rehabilitation of Hand Movement After Stroke	Phase 2
Recruiting	`NCT00001208` - Botulinum Toxin for the Treatment of Involuntary Movement Disorders
Not yet recruiting	`NCT05560269` - Verbal Cueing vs. Constraint-Led Approach for Teaching the Kettlebell Swing.	N/A
Completed	`NCT02392078` - Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System
Completed	`NCT00552474` - Deep Brain Stimulation to Treat Symptoms of Parkinson's Disease	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.