Healthy Clinical Trial
Official title:
Cortical Excitability During Self-Paced Voluntary Movements
This study will use transcranial magnetic stimulation to examine how the brain controls
movement by sending messages to the spinal cord and muscles and what goes wrong with this
process in disease. Normal healthy volunteers 18 years of age and older may be eligible to
participate.
In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's
scalp or skin. Brief electrical currents are passed through the coil, creating magnetic
pulses that stimulate the brain. During the stimulation, participants will be asked to tense
certain muscles slightly or perform other simple actions. The electrical activity of the
muscle will be recorded on a computer through electrodes applied to the skin over the
muscle. In most cases, the study will last less than 3 hours.
The purpose of this study is to investigate the influence of volitional movement on excitability of ipsilateral as well as contralateral motor cortical neurons controlling homologous and surrounding muscles. Transcallosal and surrounding inhibitions are well known phenomenon to suppress unwanted movements during voluntary action, which is often disturbed in various movement disorders. Transcranial magnetic stimulation (TMS) has been used to investigate these inhibitory mechanisms, but the inhibitory influence during and after voluntary movement has not been well elucidated yet. In normal volunteers, we plan to determine if voluntary movements of one finger influence the cortical excitability responsible for surrounding as well as contralateral homologous muscles, using voluntary movement-triggered TMS. The primary outcome measures would be any changes in motor evoked potential (MEP) size and intracortical inhibition (ICI) parameters. ;
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