Clinical Trial Details
— Status: Active, not recruiting
Administrative data
NCT number |
NCT04240028 |
Other study ID # |
2020-2029 |
Secondary ID |
|
Status |
Active, not recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
January 21, 2020 |
Est. completion date |
February 1, 2025 |
Study information
Verified date |
February 2024 |
Source |
Jewish General Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Lay Summary Older adults who are prefrail (an intermediate, potentially reversible stage
between robustness and frailty) with early symptoms of cognitive impairment are a segment of
the population that have hitherto remained "silent" and are currently not targets for
screening and intervention. These individuals require early identification for preventive
interventions to reduce disability, dependency and improve quality of life. To date, there is
still no accepted definition of individuals upstream in the spectrum of physical frailty and
cognitive impairment. Determining the prevalence and predictive ability of various
definitions of co-existent frailty and cognitive impairment could identify older adults at
greatest risk of adverse health outcomes. Therefore, the researchers aim to examine and
compare (1) the prevalence of cognitive-prefrailty, prefrailty (IANA/IAGG consensus
definition) and MCR syndromes, (2) the incidence and predictive ability of these three
syndromes for adverse health outcomes including cognitive impairment and decline, dementia,
physical functional impairment and decline, falls, hospitalization and mortality in older
Quebec community dwellers.
Description:
Scientific Summary
Background Cognitive frailty is the simultaneous presence of both physical frailty and
cognitive impairment, excluding concurrent dementia. This condition confers a greater risk of
incident cognitive impairment and decline, dementia, falls and disabilities compared to
either condition alone. Current definitions of co-existent frailty and cognitive impairment
exist, including the International Academy on Nutrition and Aging (IANA) and the
International Association of Gerontology and Geriatrics (IAGG) consensus for cognitive
frailty. There is also an analogous construct known as the motoric cognitive risk syndrome
(MCR) associating slow gait speed and subjective cognitive impairment (SCI). Current
operational criteria identify individuals later in the trajectory of frailty and cognitive
decline, which may be too late for effective interventions. The researchers propose to define
a new and early condition in the spectrum of Cognitive frailty known as
"cognitive-prefrailty", which is a combination of prefrailty stage and SCI.
Overall objective This study aims to determine and compare (1) the prevalence of
cognitive-prefrailty, cognitive frailty (IANA/IAGG consensus definition) and MCR syndromes,
(2) the incidence and predictive ability of these three syndromes for adverse health outcomes
including cognitive impairment and decline, dementia, physical functional impairment and
decline, falls, hospitalization and mortality in older community dwellers.
Methods This study will use the database of the "Nutrition as a determinant of successful
aging: The Quebec longitudinal study" (NuAge) study, which is a population-based
observational cohort hat recruited healthy community-dwellers with age ranged from 67 to 84
years (51.8% women) between November 2003 and June 2005, and followed them during 4 years.
Cognitive-prefrailty, prefrailty and MCR will be defined using information collected at the
baseline assessment. Incident adverse health outcomes including cognitive impairment and
decline, dementia, physical functional impairment and decline, falls, hospitalization and
mortality have been recorded during the 4-years follow-up period.
Anticipated results Prefrailty (an intermediate and potentially reversible stage between
robust and frailty) and SCI occur upstream in the continuum of frailty and cognitive decline
and hence constitute more suitable targets for screening and early intervention in older
adults.