Stroke Recovery Research Based on EEG-fMRI

Motor Neuropathy Clinical Trial

— EEG-fMRI  

Official title:

Motor Recovery of Stroke Patients Based on Electroencephalogram-functional Magnetic Resonance Imaging

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05427422
• Other study ID #: Stroke01
• Status: Completed
• Start date: June 30, 2022
• Est. completion date: January 30, 2024

Study information

• Verified date: February 2024
• Source: Health Science Center of Xi'an Jiaotong University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.

Description:

A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 111
• Est. completion date: January 30, 2024
• Est. primary completion date: December 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Age above 18 and below 75 years
• Motor impairment in National Institutes of Health Stroke Scale
• 7-14 days since stroke attack
• First-ever ischemic stroke

Exclusion Criteria:

• Motor impairment induced by non-stroke aetiology
• Claustrophobia; recognition disorder
• History of other severe central nervous system diseases
• Any signs unfit for MRI/EEG scan

Related Conditions & MeSH terms

• Motor Neuropathy
• Stroke

Locations

Country	Name	City	State
China	Xi'an Daxing Hospital	Xi'an	Shanxi

Sponsors (1)

Lead Sponsor	Collaborator
Health Science Center of Xi'an Jiaotong University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fugl-Meyer scores (T0)	a scale widely used to evaluate one's motor impairment	7-14 days since stroke
Primary	Fugl-Meyer scores (T1)	a scale widely used to evaluate one's motor impairment	6 weeks since stroke
Primary	Fugl-Meyer scores (T2)	a scale widely used to evaluate one's motor impairment	12 weeks since stroke
Primary	Fugl-Meyer scores (T3)	a scale widely used to evaluate one's motor impairment	72 weeks since stroke
Secondary	Neuroimage features based on EEG-fMRI (T0)	Neuroimage features extracted from EEG-fMRI data	7-14 days since stroke
Secondary	Neuroimage features based on EEG-fMRI (T1)	Neuroimage features extracted from EEG-fMRI data	6 weeks since stroke
Secondary	Neuroimage features based on EEG-fMRI (T2)	Neuroimage features extracted from EEG-fMRI data	12 weeks since stroke
Secondary	Neuroimage features based on EEG-fMRI (T3)	Neuroimage features extracted from EEG-fMRI data	72 weeks since stroke