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NCT04645433 Clinical Trial

Effect of Favipiravir on Mortality in Patients With COVID-19 at a Tertiary Center Intensive Care Unit

Mortality Clinical Trial

Official title:
Effect of Favipiravir on Mortality in Patients With COVID-19 at a Tertiary Center Intensive Care Unit: Single Center Experience

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04645433
Other study ID # 2854
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 15, 2020
Est. completion date May 15, 2020

Study information
Verified date November 2020
Source Sisli Hamidiye Etfal Training and Research Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Effect of Favipiravir and Lopinavir-Ritonavir on Mortality in a Tertiary Center Intensive Care Unit: Single Center Experience

Description:

Many agents have been given for treatment of COVID-19 infection. "Covid-19 Diagnosis and Treatment Guideline" by Ministry of Health was advised nationwide use of favipiravir or lopinavir-ritonavir although evidence was scarce for the nationwide use of lopinavir-ritonavir or favipiravir to treat COVID-19 at the time of publication date of detailed guideline Favipiravir is a RNA dependent RNA polymerase inhibitor and approved for treatment of influenza in Japan at 2014 The aim of the study was to compare ICU and hospital mortality in patients with favipiravir or lopinavir-ritonavir treatment and compare other laboratory parameters in patients treated with these two antiviral agents.

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date May 15, 2020
Est. primary completion date May 15, 2020
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - 18 Years and older Exclusion Criteria: - patients younger than 18 years old - patients who have received both lopinavir-ritonavir and favipiravir sepuentially

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Turkey SisliHamidiye Etfal Education and Training Hospital Istanbul

Sponsors (1)
Lead Sponsor Collaborator
Sisli Hamidiye Etfal Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Mortality for ICU If the patient dies, we have reached an outcome 14 days
Primary hospital stay If the hospital stay exceeds 14 days, we have reached an outcome 14 days
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