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Spermidine Intake and All-cause Mortality

Mortality Clinical Trial

Official title:
Association Between Dietary Spermidine Intake and Mortality in the Population-based Bruneck Study

Clinical Trial Summary

This study seeks to test the potential association between spermidine content in diet and mortality in humans.

Clinical Trial Description

This prospective community-based cohort study includes 829 participants aged 45-84 years, 49.9% of which are male. Diet is assessed by repeated dietician-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. Nutrient intakes including spermidine are calculated using USDA standard databases. Clinical events (all-cause mortality and cause-specific mortality) are recorded from 1995 to 2015.

The primary endpoint of all-cause mortality is related to the exposure of long-term average spermidine intake by Cox proportional hazards models with time-varying covariates. Additional analyses employ the Fine and Gray proportional subdistribution hazards model and flexible Royston-Parmar spline-based models. Comprehensive sensitivity analyses are performed to guard against potential biases associated with nutritional epidemiology. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03378843
Study type Observational
Source Medical University Innsbruck
Contact
Status Completed
Phase N/A
Start date October 1995
Completion date October 2015
View Details
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