Fish, Polyunsaturated Fatty Acids Intake and Mortality

Mortality Clinical Trial

Official title:

Fish, Polyunsaturated Fatty Acids Intake and Mortality: Analysis of CHNS and NHANES

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03155659
• Other study ID #: Cohort_PUFA
• Status: Completed
• Start date: January 1989
• Est. completion date: July 2012

Study information

• Verified date: March 2024
• Source: Zhejiang University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Data linking fish, polyunsaturated fatty acids intake and mortality are lacking and conflicting. We aim to use data from the China Health and Nutrition Survey (CHNS) and National Health and Nutrition Examination Survey (NHANES) to investigate the associations of fish and polyunsaturated fatty acids (PUFA) intake with mortality in Chinese and US populations. The study findings will be informative for addressing the role of fish and specific PUFA in human health and improve basis for dietary recommendations.

Description:

Data from the China Health and Nutrition Survey (CHNS, from 1989 to 2011) and National Health and Nutrition Examination Survey (NHANES), including NHANES III conducted in 1988-1994 and continuous NHANES 1999-2010 were used to investigate the associations of fish and polyunsaturated fatty acids intake with mortality.The following variables were used:

1. Demographics: age, sex, race/ethnicity, residence

2. Socioeconomic variables: education, marital status,

3. Dietary variables: Intakes of fish, polyunsaturated fatty acids, total energy, vegetables, fruits, red meat and saturated fat

4. Clinical assessments: hypertension, diabetes, cancer, cardiovascular disease (CVD), family history of CVD

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50145
• Est. completion date: July 2012
• Est. primary completion date: December 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Adults aged =20 with complete data on diet and follow-up time

Exclusion Criteria:

• Missing information for mortality

• Cardiovascular disease

• Cancer

Related Conditions & MeSH terms

• Mortality
• Polyunsaturated Fatty Acids

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Zhejiang University	National Institute of Health and Nutrition

References & Publications (2)

Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012 Sep 12;308(10):1024-33. doi: 10.1001/2012.jama — View Citation

Zhao LG, Sun JW, Yang Y, Ma X, Wang YY, Xiang YB. Fish consumption and all-cause mortality: a meta-analysis of cohort studies. Eur J Clin Nutr. 2016 Feb;70(2):155-61. doi: 10.1038/ejcn.2015.72. Epub 2015 May 13. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Total Mortality	Total Mortality from All Causes	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years
Secondary	Cause-specific mortality	Cause-specific mortality from diseases	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years

External Links

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